Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2348020..2348715 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag QRF10_RS11010 Protein ID WP_003410811.1
Coordinates 2348020..2348454 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag QRF10_RS11015 Protein ID WP_003410814.1
Coordinates 2348461..2348715 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS11000 (QRF10_11000) 2344174..2347215 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
QRF10_RS11005 (QRF10_11005) 2347208..2348041 + 834 WP_003899172.1 SWIM zinc finger family protein -
QRF10_RS11010 (QRF10_11010) 2348020..2348454 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF10_RS11015 (QRF10_11015) 2348461..2348715 - 255 WP_003410814.1 antitoxin Antitoxin
QRF10_RS11020 (QRF10_11020) 2348731..2348988 - 258 WP_003410816.1 hypothetical protein -
QRF10_RS11025 (QRF10_11025) 2349399..2350660 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
QRF10_RS11030 (QRF10_11030) 2351293..2351589 + 297 WP_003410820.1 PE family protein -
QRF10_RS11035 (QRF10_11035) 2351645..2352376 + 732 WP_003900467.1 PPE family protein -
QRF10_RS11040 (QRF10_11040) 2352917..2353663 - 747 WP_003906749.1 proteasome subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T283846 WP_003410811.1 NZ_CP127274:c2348454-2348020 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT283846 WP_003410814.1 NZ_CP127274:c2348715-2348461 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References