Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2304765..2305401 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag QRF10_RS10815 Protein ID WP_003410654.1
Coordinates 2304991..2305401 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag QRF10_RS10810 Protein ID WP_003410651.1
Coordinates 2304765..2304998 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS10795 (QRF10_10795) 2300222..2300614 + 393 WP_229303073.1 metal ABC transporter permease -
QRF10_RS10800 (QRF10_10800) 2300615..2301019 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
QRF10_RS10805 (QRF10_10805) 2301103..2304687 - 3585 WP_286018031.1 cobaltochelatase subunit CobN -
QRF10_RS10810 (QRF10_10810) 2304765..2304998 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
QRF10_RS10815 (QRF10_10815) 2304991..2305401 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
QRF10_RS10820 (QRF10_10820) 2305385..2306476 + 1092 WP_003900454.1 precorrin-3B synthase -
QRF10_RS10825 (QRF10_10825) 2306486..2307112 + 627 WP_003410658.1 precorrin-8X methylmutase -
QRF10_RS10830 (QRF10_10830) 2307109..2308635 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
QRF10_RS10835 (QRF10_10835) 2308581..2309804 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T283845 WP_003410654.1 NZ_CP127274:2304991-2305401 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT283845 WP_003410651.1 NZ_CP127274:2304765-2304998 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References