Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2218239..2218825 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QRF10_RS10430 Protein ID WP_003912702.1
Coordinates 2218239..2218583 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag QRF10_RS10435 Protein ID WP_003410014.1
Coordinates 2218577..2218825 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS10395 (QRF10_10395) 2213945..2214544 + 600 WP_003409989.1 L-lysine exporter -
QRF10_RS10400 (QRF10_10400) 2214960..2215388 + 429 WP_003409992.1 cellulose-binding protein -
QRF10_RS10405 (QRF10_10405) 2215614..2216153 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
QRF10_RS10410 (QRF10_10410) 2216673..2217233 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
QRF10_RS10415 (QRF10_10415) 2217230..2217571 - 342 WP_003410003.1 DUF2384 domain-containing protein -
QRF10_RS10420 (QRF10_10420) 2217657..2217914 + 258 WP_003410006.1 hypothetical protein -
QRF10_RS10425 (QRF10_10425) 2217815..2218150 - 336 WP_003410009.1 dehydrogenase -
QRF10_RS10430 (QRF10_10430) 2218239..2218583 - 345 WP_003912702.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
QRF10_RS10435 (QRF10_10435) 2218577..2218825 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
QRF10_RS10440 (QRF10_10440) 2218925..2221240 - 2316 WP_003899120.1 cation transporter ATPase CptG -
QRF10_RS10445 (QRF10_10445) 2221237..2221509 - 273 WP_003410017.1 DUF1490 family protein -
QRF10_RS10450 (QRF10_10450) 2221562..2221918 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
QRF10_RS10455 (QRF10_10455) 2222075..2222842 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12260.15 Da        Isoelectric Point: 9.8887

>T283842 WP_003912702.1 NZ_CP127274:c2218583-2218239 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPSNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT283842 WP_003410014.1 NZ_CP127274:c2218825-2218577 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7WJ0
PDB 7WNR
AlphaFold DB A0A7U4FAW9

References