Detailed information of TA system TA028384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1791620..1792281
• Replicon: chromosome
• Accession: NC_018691
• Organism: Alcanivorax dieselolei B5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: K0C8W7
• Locus tag: B5T_RS08210
• Protein ID: WP_014994025.1
• Coordinates: 1791620..1792042 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K0CBU8
• Locus tag: B5T_RS08215
• Protein ID: WP_014994026.1
• Coordinates: 1792039..1792281 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B5T_RS08195	1788336..1789094	-	759	WP_014994022.1	class II aldolase/adducin family protein	-
B5T_RS08200	1789337..1790296	-	960	WP_014994023.1	zinc-binding dehydrogenase	-
B5T_RS08205	1790460..1791482	+	1023	WP_014994024.1	MBL fold metallo-hydrolase	-
B5T_RS08210	1791620..1792042	-	423	WP_014994025.1	type II toxin-antitoxin system VapC family toxin	Toxin
B5T_RS08215	1792039..1792281	-	243	WP_014994026.1	plasmid stabilization protein	Antitoxin
B5T_RS08220	1792391..1793227	-	837	WP_041716939.1	IclR family transcriptional regulator	-
B5T_RS08225	1793614..1795776	+	2163	WP_014994028.1	acetate--CoA ligase family protein	-
B5T_RS08230	1795784..1796626	+	843	WP_014994029.1	MaoC family dehydratase N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15412.88 Da
• Isoelectric Point: 7.9170

>T28384 WP_014994025.1 NC_018691:c1792042-1791620 [Alcanivorax dieselolei B5]
MIVLDTNVLSDLMRPAPDPRVVAWLDRQPGRDVAVTSITVAEILHGVRRLPAGRRKRQLTDLSVDLFNEEFAGRVLPFDA
PAAAHYAEKLAACEKRGRPVHMADVQIAAICERHGAVLATRNIKDFEPLGVSLLNPWMAG

Nucleotide

• Length: 423 bp

>T28384 NC_018691:c1792042-1791620 [Alcanivorax dieselolei B5]
ATGATTGTCCTGGACACCAATGTGCTGTCGGACTTGATGCGGCCGGCGCCCGACCCCCGGGTAGTGGCGTGGCTGGACCG
CCAGCCCGGCCGGGATGTGGCGGTTACCAGCATCACCGTGGCGGAAATACTGCATGGCGTCCGCCGCTTGCCCGCCGGGC
GACGCAAGCGCCAGCTCACGGACCTGTCCGTAGATTTGTTCAACGAGGAGTTCGCCGGCCGCGTGCTGCCTTTCGACGCC
CCGGCCGCCGCCCACTACGCGGAAAAACTGGCGGCCTGCGAAAAACGCGGCCGGCCCGTGCACATGGCCGACGTTCAGAT
CGCCGCCATCTGCGAGCGGCACGGCGCTGTACTGGCCACGCGCAATATCAAGGATTTCGAACCCTTGGGGGTGTCTTTAC
TGAATCCGTGGATGGCGGGTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9138.14 Da
• Isoelectric Point: 5.1802

>AT28384 WP_014994026.1 NC_018691:c1792281-1792039 [Alcanivorax dieselolei B5]
MASITIRNLDDELKARLRLSAAEHGHSMEEEVRQILHRALEPGSDTGLGTRIRERFAAYDAEPPEFERRRDAPRDPGLDQ

Nucleotide

• Length: 243 bp

>AT28384 NC_018691:c1792281-1792039 [Alcanivorax dieselolei B5]
ATGGCCTCCATTACCATCCGCAACCTCGATGACGAATTGAAAGCCCGGCTGCGCTTGAGCGCCGCTGAACACGGCCATTC
CATGGAGGAAGAGGTAAGGCAGATCCTGCATCGTGCCCTGGAGCCGGGTTCGGATACCGGTCTTGGCACCCGCATCCGCG
AGCGCTTTGCCGCCTATGATGCCGAACCGCCGGAGTTCGAACGGCGCCGGGACGCGCCCCGCGATCCTGGTCTGGATCAA
TGA

Structures

Toxin

• AlphaFold DB: K0C8W7

Antitoxin

• AlphaFold DB: K0CBU8