Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2178578..2179281 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag QRF10_RS10155 Protein ID WP_003409778.1
Coordinates 2178578..2178907 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag QRF10_RS10160 Protein ID WP_003409780.1
Coordinates 2178904..2179281 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS10135 (QRF10_10135) 2174961..2176031 + 1071 WP_003899091.1 epoxide hydrolase EphB -
QRF10_RS10140 (QRF10_10140) 2176028..2176543 + 516 WP_003409718.1 flavin reductase family protein -
QRF10_RS10145 (QRF10_10145) 2176540..2177601 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
QRF10_RS10150 (QRF10_10150) 2177598..2178368 + 771 WP_003409775.1 SDR family oxidoreductase -
QRF10_RS10155 (QRF10_10155) 2178578..2178907 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QRF10_RS10160 (QRF10_10160) 2178904..2179281 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
QRF10_RS10165 (QRF10_10165) 2179278..2179868 - 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
QRF10_RS10170 (QRF10_10170) 2179923..2181287 + 1365 WP_003903691.1 HNH endonuclease signature motif containing protein -
QRF10_RS10175 (QRF10_10175) 2181442..2181894 - 453 WP_003899095.1 lipoprotein -
QRF10_RS10180 (QRF10_10180) 2181958..2182359 + 402 WP_003409869.1 hypothetical protein -
QRF10_RS10185 (QRF10_10185) 2182352..2182534 - 183 WP_003409870.1 hypothetical protein -
QRF10_RS10190 (QRF10_10190) 2182648..2182998 - 351 WP_003899096.1 hypothetical protein -
QRF10_RS10195 (QRF10_10195) 2183009..2183911 - 903 WP_003899097.1 hypothetical protein -
QRF10_RS10200 (QRF10_10200) 2183932..2184123 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T283837 WP_003409778.1 NZ_CP127274:c2178907-2178578 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT283837 WP_003409780.1 NZ_CP127274:c2179281-2178904 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References