Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1937797..1938410 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag QRF10_RS09060 Protein ID WP_003408465.1
Coordinates 1937797..1938186 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag QRF10_RS09065 Protein ID WP_003408469.1
Coordinates 1938183..1938410 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS09025 (QRF10_09025) 1933426..1934340 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
QRF10_RS09030 (QRF10_09030) 1934343..1935173 + 831 WP_003408448.1 cyclase family protein -
QRF10_RS09035 (QRF10_09035) 1935173..1935523 + 351 WP_003898986.1 cupin domain-containing protein -
QRF10_RS09040 (QRF10_09040) 1935576..1936394 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
QRF10_RS09045 (QRF10_09045) 1936408..1937187 + 780 WP_003408460.1 IclR family transcriptional regulator -
QRF10_RS09055 (QRF10_09055) 1937618..1937749 + 132 Protein_1786 IS3 family transposase -
QRF10_RS09060 (QRF10_09060) 1937797..1938186 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF10_RS09065 (QRF10_09065) 1938183..1938410 - 228 WP_003408469.1 antitoxin Antitoxin
QRF10_RS09070 (QRF10_09070) 1938628..1940112 + 1485 WP_003408473.1 biotin carboxylase -
QRF10_RS09075 (QRF10_09075) 1940109..1941356 + 1248 WP_003408476.1 serine hydrolase -
QRF10_RS09080 (QRF10_09080) 1941399..1941818 - 420 WP_003408483.1 hypothetical protein -
QRF10_RS09085 (QRF10_09085) 1941808..1942518 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T283835 WP_003408465.1 NZ_CP127274:c1938186-1937797 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT283835 WP_003408469.1 NZ_CP127274:c1938410-1938183 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References