Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1686270..1686886 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag QRF10_RS07965 Protein ID WP_003407593.1
Coordinates 1686569..1686886 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag QRF10_RS07960 Protein ID WP_003900349.1
Coordinates 1686270..1686572 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS07950 (QRF10_07950) 1682156..1684003 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
QRF10_RS07955 (QRF10_07955) 1684004..1686256 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
QRF10_RS07960 (QRF10_07960) 1686270..1686572 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
QRF10_RS07965 (QRF10_07965) 1686569..1686886 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
QRF10_RS07970 (QRF10_07970) 1686883..1687887 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
QRF10_RS07975 (QRF10_07975) 1687940..1689229 + 1290 WP_003407599.1 serine hydrolase domain-containing protein -
QRF10_RS07980 (QRF10_07980) 1689302..1690027 - 726 WP_003898898.1 class I SAM-dependent methyltransferase -
QRF10_RS07985 (QRF10_07985) 1690133..1690345 - 213 WP_003898900.1 dodecin family protein -
QRF10_RS07990 (QRF10_07990) 1690406..1690804 + 399 WP_003900351.1 hypothetical protein -
QRF10_RS07995 (QRF10_07995) 1690849..1691877 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T283833 WP_003407593.1 NZ_CP127274:1686569-1686886 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT283833 WP_003900349.1 NZ_CP127274:1686270-1686572 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References