Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1538389..1539439 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name phRel Uniprot ID -
Locus tag QRF10_RS07310 Protein ID WP_003912801.1
Coordinates 1538389..1539210 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag QRF10_RS07315 Protein ID WP_003407167.1
Coordinates 1539203..1539439 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS07290 (QRF10_07290) 1533947..1534609 - 663 WP_003407152.1 membrane protein -
QRF10_RS07295 (QRF10_07295) 1534606..1535391 - 786 WP_003407157.1 membrane protein -
QRF10_RS07300 (QRF10_07300) 1535682..1537643 - 1962 WP_003407159.1 sigma-F factor regulator -
QRF10_RS07305 (QRF10_07305) 1537782..1538168 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
QRF10_RS07310 (QRF10_07310) 1538389..1539210 + 822 WP_003912801.1 GTP pyrophosphokinase family protein Toxin
QRF10_RS07315 (QRF10_07315) 1539203..1539439 + 237 WP_003407167.1 hypothetical protein Antitoxin
QRF10_RS07320 (QRF10_07320) 1539511..1540716 - 1206 WP_003898846.1 serine hydrolase domain-containing protein -
QRF10_RS07325 (QRF10_07325) 1541019..1541804 + 786 WP_003407180.1 lipoprotein LprF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30134.12 Da        Isoelectric Point: 5.8187

>T283832 WP_003912801.1 NZ_CP127274:1538389-1539210 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADFLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT283832 WP_003407167.1 NZ_CP127274:1539203-1539439 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References