Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1388684..1389243 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag QRF10_RS06660 Protein ID WP_003898789.1
Coordinates 1388684..1388977 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag QRF10_RS06665 Protein ID WP_003406322.1
Coordinates 1388974..1389243 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS06635 (QRF10_06635) 1384277..1384537 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
QRF10_RS06640 (QRF10_06640) 1384534..1384965 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
QRF10_RS06645 (QRF10_06645) 1384988..1386676 - 1689 WP_003910308.1 PE family protein -
QRF10_RS06650 (QRF10_06650) 1386856..1387716 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
QRF10_RS06655 (QRF10_06655) 1387797..1388627 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
QRF10_RS06660 (QRF10_06660) 1388684..1388977 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QRF10_RS06665 (QRF10_06665) 1388974..1389243 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QRF10_RS06670 (QRF10_06670) 1389356..1393051 - 3696 WP_003898790.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
QRF10_RS06675 (QRF10_06675) 1393193..1393981 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T283831 WP_003898789.1 NZ_CP127274:c1388977-1388684 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT283831 WP_003406322.1 NZ_CP127274:c1389243-1388974 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References