Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1384277..1384965 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag QRF10_RS06640 Protein ID WP_003406304.1
Coordinates 1384534..1384965 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag QRF10_RS06635 Protein ID WP_003406302.1
Coordinates 1384277..1384537 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS06615 (QRF10_06615) 1379854..1380678 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
QRF10_RS06620 (QRF10_06620) 1380683..1381864 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
QRF10_RS06625 (QRF10_06625) 1381941..1383041 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
QRF10_RS06630 (QRF10_06630) 1383212..1384201 + 990 WP_003406301.1 malate dehydrogenase -
QRF10_RS06635 (QRF10_06635) 1384277..1384537 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
QRF10_RS06640 (QRF10_06640) 1384534..1384965 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF10_RS06645 (QRF10_06645) 1384988..1386676 - 1689 WP_003910308.1 PE family protein -
QRF10_RS06650 (QRF10_06650) 1386856..1387716 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
QRF10_RS06655 (QRF10_06655) 1387797..1388627 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
QRF10_RS06660 (QRF10_06660) 1388684..1388977 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
QRF10_RS06665 (QRF10_06665) 1388974..1389243 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T283830 WP_003406304.1 NZ_CP127274:1384534-1384965 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT283830 WP_003406302.1 NZ_CP127274:1384277-1384537 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References