Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1014680..1015299 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag QRF10_RS04830 Protein ID WP_003404726.1
Coordinates 1014865..1015299 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag QRF10_RS04825 Protein ID WP_003898641.1
Coordinates 1014680..1014859 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS04810 (QRF10_04810) 1010154..1011733 + 1580 Protein_948 serine hydrolase -
QRF10_RS04815 (QRF10_04815) 1011730..1014123 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
QRF10_RS04820 (QRF10_04820) 1014396..1014554 + 159 WP_003404720.1 hypothetical protein -
QRF10_RS04825 (QRF10_04825) 1014680..1014859 + 180 WP_003898641.1 antitoxin Antitoxin
QRF10_RS04830 (QRF10_04830) 1014865..1015299 + 435 WP_003404726.1 SRPBCC family protein Toxin
QRF10_RS04835 (QRF10_04835) 1015397..1016170 + 774 WP_003404735.1 VOC family protein -
QRF10_RS04840 (QRF10_04840) 1016235..1016684 + 450 WP_003404738.1 hypothetical protein -
QRF10_RS04845 (QRF10_04845) 1016819..1017049 - 231 WP_003898642.1 hypothetical protein -
QRF10_RS04850 (QRF10_04850) 1017216..1018724 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
QRF10_RS04855 (QRF10_04855) 1018726..1019964 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T283825 WP_003404726.1 NZ_CP127274:1014865-1015299 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT283825 WP_003898641.1 NZ_CP127274:1014680-1014859 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References