Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1208649..1209148 Replicon plasmid pSYMA
Accession NC_018683
Organism Sinorhizobium meliloti Rm41

Toxin (Protein)


Gene name relE Uniprot ID Q92YA6
Locus tag BN406_RS24550 Protein ID WP_010967939.1
Coordinates 1208649..1208822 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A843ZXX9
Locus tag BN406_RS37725 Protein ID WP_014990215.1
Coordinates 1208819..1209148 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN406_RS24525 1204513..1205829 + 1317 WP_013845634.1 aspartate aminotransferase family protein -
BN406_RS24530 1206208..1206693 - 486 WP_010967936.1 YidB family protein -
BN406_RS24535 1206721..1206972 - 252 WP_003534243.1 GlsB/YeaQ/YmgE family stress response membrane protein -
BN406_RS24540 1207567..1207926 + 360 WP_013845635.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
BN406_RS24545 1208246..1208551 + 306 WP_013845638.1 hypothetical protein -
BN406_RS24550 1208649..1208822 - 174 WP_010967939.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BN406_RS37725 1208819..1209148 - 330 WP_014990215.1 hypothetical protein Antitoxin
BN406_RS35765 1209083..1209268 + 186 WP_013845639.1 hypothetical protein -
BN406_RS24560 1209509..1210879 + 1371 WP_013845640.1 alpha/beta hydrolase -
BN406_RS24565 1211263..1211604 + 342 Protein_1158 hypothetical protein -
BN406_RS24570 1211588..1211926 - 339 WP_013845641.1 SDR family oxidoreductase -
BN406_RS24575 1212043..1212486 - 444 WP_010967942.1 PACE efflux transporter -
BN406_RS24580 1212578..1213471 + 894 WP_010967943.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aac(3)-IIc htpB 1..1559666 1559666


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-82)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6497.32 Da        Isoelectric Point: 5.7733

>T28382 WP_010967939.1 NC_018683:c1208822-1208649 [Sinorhizobium meliloti Rm41]
MKLVWARYALDDRDAIFSYIERENPRAAVHVDEEVVSAGRPLDFPESRRPGRIAGTP

Download         Length: 174 bp

>T28382 NC_018683:c1208822-1208649 [Sinorhizobium meliloti Rm41]
ATGAAGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACGCCATCTTCAGCTACATCGAACGAGAGAATCCGAGGGC
GGCGGTCCACGTTGACGAGGAGGTCGTCAGCGCTGGTCGTCCGCTGGACTTTCCCGAAAGCCGCCGCCCTGGCCGGATTG
CCGGAACTCCATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12067.72 Da        Isoelectric Point: 11.1401

>AT28382 WP_014990215.1 NC_018683:c1209148-1208819 [Sinorhizobium meliloti Rm41]
VSERLLLIALLALGPFRASQRHTGRPALLRRGPQTAAGAVEEHFIQLRAPLWLITLGGFSHREAHDAWFRAKVLRALEDT
RPDADDADADAHFQERRAAALRKAAAGDR

Download         Length: 330 bp

>AT28382 NC_018683:c1209148-1208819 [Sinorhizobium meliloti Rm41]
GTGAGCGAGCGCCTTCTGCTCATCGCCCTCCTGGCCCTCGGTCCGTTCCGAGCCAGCCAGCGGCATACCGGTCGTCCTGC
TCTGCTACGGCGTGGCCCCCAAACGGCCGCCGGCGCGGTCGAGGAGCACTTCATCCAACTCCGCGCTCCGCTGTGGCTGA
TCACGCTCGGCGGTTTCAGCCACAGAGAGGCTCACGACGCTTGGTTCCGCGCCAAAGTTTTGCGGGCACTCGAGGACACT
CGACCCGATGCGGACGACGCCGACGCCGATGCGCACTTTCAAGAGCGCCGCGCCGCAGCTTTGCGCAAGGCTGCGGCGGG
TGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92YA6

Antitoxin

Source ID Structure
AlphaFold DB A0A843ZXX9

References