Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 703243..703886 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag QRF10_RS03210 Protein ID WP_003403187.1
Coordinates 703485..703886 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag QRF10_RS03205 Protein ID WP_003403184.1
Coordinates 703243..703488 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS03170 (QRF10_03170) 698523..699053 - 531 WP_003917320.1 two component system sensor kinase HK2 -
QRF10_RS03175 (QRF10_03175) 699037..699732 - 696 WP_003918099.1 two-component system response regulator TcrA -
QRF10_RS03180 (QRF10_03180) 699855..700166 + 312 WP_003403164.1 hypothetical protein -
QRF10_RS03185 (QRF10_03185) 700238..701188 + 951 WP_003900184.1 DUF1259 domain-containing protein -
QRF10_RS03190 (QRF10_03190) 701429..702013 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
QRF10_RS03195 (QRF10_03195) 702015..702725 + 711 Protein_633 IS607 family element RNA-guided endonuclease TnpB -
QRF10_RS03200 (QRF10_03200) 702728..703198 + 471 WP_003898523.1 hypothetical protein -
QRF10_RS03205 (QRF10_03205) 703243..703488 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRF10_RS03210 (QRF10_03210) 703485..703886 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF10_RS03215 (QRF10_03215) 703877..704056 + 180 Protein_637 hypothetical protein -
QRF10_RS03220 (QRF10_03220) 704474..704671 - 198 WP_003403191.1 hypothetical protein -
QRF10_RS03225 (QRF10_03225) 704751..705908 - 1158 WP_286018065.1 hypothetical protein -
QRF10_RS03230 (QRF10_03230) 705960..706181 - 222 WP_003898525.1 DUF4926 domain-containing protein -
QRF10_RS03235 (QRF10_03235) 706323..706928 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T283816 WP_003403187.1 NZ_CP127274:703485-703886 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT283816 WP_003403184.1 NZ_CP127274:703243-703488 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References