Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 640227..640903 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag QRF10_RS02905 Protein ID WP_003898500.1
Coordinates 640227..640640 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag QRF10_RS02910 Protein ID WP_003402915.1
Coordinates 640637..640903 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS02875 (QRF10_02875) 635572..635874 - 303 WP_003402896.1 DUF3349 domain-containing protein -
QRF10_RS02880 (QRF10_02880) 635934..636212 - 279 WP_003402901.1 hypothetical protein -
QRF10_RS02885 (QRF10_02885) 636209..637462 - 1254 WP_003402904.1 inorganic phosphate transporter -
QRF10_RS02890 (QRF10_02890) 637582..637968 - 387 WP_003402907.1 VOC family protein -
QRF10_RS02895 (QRF10_02895) 638031..638915 - 885 WP_003402909.1 SDR family oxidoreductase -
QRF10_RS02900 (QRF10_02900) 639011..639913 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
QRF10_RS02905 (QRF10_02905) 640227..640640 - 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF10_RS02910 (QRF10_02910) 640637..640903 - 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QRF10_RS02915 (QRF10_02915) 641095..642810 - 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
QRF10_RS02920 (QRF10_02920) 642888..644492 + 1605 WP_003402920.1 amidohydrolase -
QRF10_RS02925 (QRF10_02925) 644489..645469 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T283812 WP_003898500.1 NZ_CP127274:c640640-640227 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT283812 WP_003402915.1 NZ_CP127274:c640903-640637 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References