Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 363825..364468 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag QRF10_RS01595 Protein ID WP_003401566.1
Coordinates 364043..364468 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag QRF10_RS01590 Protein ID WP_003401563.1
Coordinates 363825..364046 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS01565 (QRF10_01565) 358944..359747 - 804 WP_003401540.1 Stf0 family sulphotransferase -
QRF10_RS01570 (QRF10_01570) 359757..361154 - 1398 WP_003914582.1 sulfatase -
QRF10_RS01575 (QRF10_01575) 361333..363108 + 1776 WP_010886074.1 PE family protein -
QRF10_RS01580 (QRF10_01580) 363251..363478 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
QRF10_RS01585 (QRF10_01585) 363475..363777 + 303 WP_003401560.1 toxin-antitoxin system toxin -
QRF10_RS01590 (QRF10_01590) 363825..364046 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
QRF10_RS01595 (QRF10_01595) 364043..364468 + 426 WP_003401566.1 PIN domain nuclease Toxin
QRF10_RS01600 (QRF10_01600) 364604..365236 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
QRF10_RS01605 (QRF10_01605) 365233..366141 + 909 WP_003900117.1 protochlorophyllide reductase -
QRF10_RS01610 (QRF10_01610) 366149..366739 - 591 WP_229298012.1 hypothetical protein -
QRF10_RS01615 (QRF10_01615) 366732..366782 - 51 Protein_319 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T283810 WP_003401566.1 NZ_CP127274:364043-364468 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT283810 WP_003401563.1 NZ_CP127274:363825-364046 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References