Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3809250..3809935 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag QQ046_RS17940 Protein ID WP_003417998.1
Coordinates 3809525..3809935 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QQ046_RS17935 Protein ID WP_180895138.1
Coordinates 3809250..3809528 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS17915 (QQ046_17915) 3805239..3806840 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
QQ046_RS17920 (QQ046_17920) 3806857..3807561 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
QQ046_RS17925 (QQ046_17925) 3807679..3808245 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
QQ046_RS17930 (QQ046_17930) 3808307..3809194 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
QQ046_RS17935 (QQ046_17935) 3809250..3809528 + 279 WP_180895138.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QQ046_RS17940 (QQ046_17940) 3809525..3809935 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ046_RS17945 (QQ046_17945) 3809968..3811704 - 1737 WP_003418002.1 cholesterol oxidase -
QQ046_RS17950 (QQ046_17950) 3811760..3812887 - 1128 WP_031718924.1 GuaB3 family IMP dehydrogenase-related protein -
QQ046_RS17955 (QQ046_17955) 3812907..3814496 - 1590 WP_003901630.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-58)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T283806 WP_003417998.1 NZ_CP127273:3809525-3809935 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10227.70 Da        Isoelectric Point: 8.0222

>AT283806 WP_180895138.1 NZ_CP127273:3809250-3809528 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGCKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References