Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3753750..3754279 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag QQ046_RS17680 Protein ID WP_003417760.1
Coordinates 3754022..3754279 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag QQ046_RS17675 Protein ID WP_003417757.1
Coordinates 3753750..3754025 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS17640 (QQ046_17640) 3750323..3751012 - 690 WP_003917774.1 BBE domain-containing protein -
QQ046_RS17645 (QQ046_17645) 3751199..3751570 - 372 WP_003417739.1 FAD-binding protein -
QQ046_RS17650 (QQ046_17650) 3751468..3751686 - 219 WP_157132559.1 hypothetical protein -
QQ046_RS17655 (QQ046_17655) 3751713..3751973 - 261 WP_003417741.1 hypothetical protein -
QQ046_RS17660 (QQ046_17660) 3752088..3752477 + 390 WP_003417745.1 DUF732 domain-containing protein -
QQ046_RS17665 (QQ046_17665) 3752491..3752784 - 294 WP_003417749.1 DUF3017 domain-containing protein -
QQ046_RS17670 (QQ046_17670) 3752781..3753626 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
QQ046_RS17675 (QQ046_17675) 3753750..3754025 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
QQ046_RS17680 (QQ046_17680) 3754022..3754279 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
QQ046_RS17685 (QQ046_17685) 3754321..3755511 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
QQ046_RS17690 (QQ046_17690) 3755628..3755996 + 369 WP_003417765.1 FHA domain-containing protein -
QQ046_RS17695 (QQ046_17695) 3755993..3756544 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
QQ046_RS17700 (QQ046_17700) 3756551..3757132 - 582 WP_003417769.1 ATP/GTP-binding protein -
QQ046_RS17705 (QQ046_17705) 3757113..3757481 - 369 WP_003417772.1 DUF742 domain-containing protein -
QQ046_RS17710 (QQ046_17710) 3757459..3757851 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T283804 WP_003417760.1 NZ_CP127273:3754022-3754279 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT283804 WP_003417757.1 NZ_CP127273:3753750-3754025 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References