Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3690619..3691293 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag QQ046_RS17480 Protein ID WP_003417282.1
Coordinates 3690619..3691047 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag QQ046_RS17485 Protein ID WP_003417286.1
Coordinates 3691051..3691293 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS17455 (QQ046_17455) 3686441..3686842 - 402 WP_003417264.1 cytidine deaminase -
QQ046_RS17460 (QQ046_17460) 3687079..3687417 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
QQ046_RS17465 (QQ046_17465) 3687414..3687848 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
QQ046_RS17470 (QQ046_17470) 3687977..3689749 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
QQ046_RS17475 (QQ046_17475) 3689749..3690540 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
QQ046_RS17480 (QQ046_17480) 3690619..3691047 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ046_RS17485 (QQ046_17485) 3691051..3691293 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
QQ046_RS17490 (QQ046_17490) 3691415..3692029 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
QQ046_RS17495 (QQ046_17495) 3692026..3692691 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
QQ046_RS17500 (QQ046_17500) 3692692..3693225 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
QQ046_RS17505 (QQ046_17505) 3693222..3693356 - 135 Protein_3457 4a-hydroxytetrahydrobiopterin dehydratase -
QQ046_RS17510 (QQ046_17510) 3693410..3694671 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T283803 WP_003417282.1 NZ_CP127273:c3691047-3690619 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT283803 WP_003417286.1 NZ_CP127273:c3691293-3691051 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References