Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3166115..3166802 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag QQ046_RS15110 Protein ID WP_003414624.1
Coordinates 3166359..3166802 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag QQ046_RS15105 Protein ID WP_003414620.1
Coordinates 3166115..3166372 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS15085 (QQ046_15085) 3161435..3162289 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
QQ046_RS15090 (QQ046_15090) 3162345..3163508 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
QQ046_RS15095 (QQ046_15095) 3163525..3164739 - 1215 WP_003414610.1 zinc metalloprotease Rip -
QQ046_RS15100 (QQ046_15100) 3164747..3165988 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
QQ046_RS15105 (QQ046_15105) 3166115..3166372 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
QQ046_RS15110 (QQ046_15110) 3166359..3166802 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ046_RS15115 (QQ046_15115) 3166882..3167544 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
QQ046_RS15120 (QQ046_15120) 3167640..3167831 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
QQ046_RS15125 (QQ046_15125) 3168163..3169911 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
QQ046_RS15130 (QQ046_15130) 3170007..3170588 + 582 WP_003414644.1 fasciclin domain-containing protein -
QQ046_RS15135 (QQ046_15135) 3170688..3170954 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T283801 WP_003414624.1 NZ_CP127273:3166359-3166802 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT283801 WP_003414620.1 NZ_CP127273:3166115-3166372 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References