Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3093149..3093719 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag QQ046_RS14730 Protein ID WP_003414166.1
Coordinates 3093149..3093505 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag QQ046_RS14735 Protein ID WP_003901465.1
Coordinates 3093489..3093719 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS14710 (QQ046_14710) 3088601..3090289 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
QQ046_RS14715 (QQ046_14715) 3090293..3090619 - 327 WP_003414157.1 hypothetical protein -
QQ046_RS14720 (QQ046_14720) 3090792..3091379 + 588 WP_003914429.1 DUF3558 family protein -
QQ046_RS14725 (QQ046_14725) 3091398..3093047 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
QQ046_RS14730 (QQ046_14730) 3093149..3093505 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
QQ046_RS14735 (QQ046_14735) 3093489..3093719 - 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
QQ046_RS14740 (QQ046_14740) 3093762..3094805 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
QQ046_RS14745 (QQ046_14745) 3094804..3095271 + 468 WP_003414177.1 DUF1778 domain-containing protein -
QQ046_RS14750 (QQ046_14750) 3095447..3095701 - 255 WP_003917684.1 hypothetical protein -
QQ046_RS14755 (QQ046_14755) 3095849..3096253 + 405 WP_003414181.1 hypothetical protein -
QQ046_RS14760 (QQ046_14760) 3096250..3096441 + 192 WP_003414184.1 hypothetical protein -
QQ046_RS14765 (QQ046_14765) 3096658..3096918 + 261 Protein_2914 transposase -
QQ046_RS14770 (QQ046_14770) 3098028..3098285 + 258 WP_003899489.1 hypothetical protein -
QQ046_RS14775 (QQ046_14775) 3098390..3098701 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T283797 WP_003414166.1 NZ_CP127273:c3093505-3093149 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT283797 WP_003901465.1 NZ_CP127273:c3093719-3093489 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References