Detailed information of TA system TA028379

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 375331..375929
• Replicon: plasmid pSYMA
• Accession: NC_018683
• Organism: Sinorhizobium meliloti Rm41

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q930F0
• Locus tag: BN406_RS20640
• Protein ID: WP_010967243.1
• Coordinates: 375636..375929 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BN406_RS20635
• Protein ID: WP_014989717.1
• Coordinates: 375331..375639 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN406_RS20615	370340..371152	+	813	WP_014531227.1	3-oxoacyl-ACP reductase FabG	-
BN406_RS20620	371290..372105	+	816	WP_014531228.1	shikimate dehydrogenase	-
BN406_RS20625	372105..373514	+	1410	WP_014531229.1	FAD-binding oxidoreductase	-
BN406_RS20630	373511..375121	+	1611	WP_014989716.1	GMC family oxidoreductase N-terminal domain-containing protein	-
BN406_RS20635	375331..375639	+	309	WP_014989717.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BN406_RS20640	375636..375929	+	294	WP_010967243.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
BN406_RS20645	376191..377390	-	1200	WP_014989718.1	NAD-dependent formate dehydrogenase	-
BN406_RS20650	377784..378551	+	768	Protein_367	ParB N-terminal domain-containing protein	-
BN406_RS20655	378929..379705	-	777	WP_014989720.1	histidinol-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	aac(3)-IIc	htpB	1..1559666	1559666

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-53)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11278.93 Da
• Isoelectric Point: 6.4734

>T28379 WP_010967243.1 NC_018683:375636-375929 [Sinorhizobium meliloti Rm41]
MRLVWARYALDDRDTIFSYIERENPRAAVHVDEEIVSAVRRLLDFPESGRPGRIAGTRELVIPRTPYIAAYMVMEDRIRI
LRVLHGAQKWPSELDDG

Nucleotide

• Length: 294 bp

>T28379 NC_018683:375636-375929 [Sinorhizobium meliloti Rm41]
ATGAGGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACACCATCTTCAGTTACATCGAAAGGGAGAATCCGAGGGC
GGCGGTCCACGTCGACGAGGAGATCGTCAGCGCGGTACGTCGTCTGCTTGATTTTCCGGAAAGCGGCCGCCCTGGCCGGA
TTGCCGGAACTCGAGAGCTTGTTATCCCTCGGACCCCCTACATTGCAGCCTACATGGTAATGGAGGATAGAATTCGAATT
CTGCGTGTCCTGCACGGCGCCCAGAAGTGGCCCAGCGAGCTCGACGACGGGTAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11228.61 Da
• Isoelectric Point: 5.6604

>AT28379 WP_014989717.1 NC_018683:375331-375639 [Sinorhizobium meliloti Rm41]
MASNALVQTRIDAEVKERATAVLENMGLTVSDAVRILLTRTANEGALPLELFSHSEAHDAWFRAKVLRALEDTRPDVDDA
DADAHFRERRAAAMRKAAAGDR

Nucleotide

• Length: 309 bp

>AT28379 NC_018683:375331-375639 [Sinorhizobium meliloti Rm41]
ATGGCTTCAAATGCACTTGTTCAGACTCGAATCGATGCCGAGGTCAAAGAGCGCGCCACGGCGGTTTTAGAGAACATGGG
TCTGACGGTCTCGGACGCTGTTCGAATCCTGTTAACTCGGACGGCGAATGAGGGCGCCCTGCCGCTGGAACTCTTCAGCC
ACAGCGAGGCGCACGACGCTTGGTTCCGCGCCAAAGTGTTGCGGGCACTCGAGGATACCCGACCCGACGTCGACGATGCC
GACGCCGATGCGCACTTTCGAGAGCGCCGGGCGGCAGCTATGCGCAAGGCTGCGGCGGGTGATCGATGA

Structures

Toxin

• AlphaFold DB: Q930F0