283789

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2837249..2837889 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag QQ046_RS13310 Protein ID WP_003412970.1
Coordinates 2837249..2837668 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag QQ046_RS13315 Protein ID WP_003412975.1
Coordinates 2837665..2837889 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS13280 (QQ046_13280) 2832834..2833556 - 723 WP_003412957.1 DUF1906 domain-containing protein -
QQ046_RS13285 (QQ046_13285) 2834073..2834300 + 228 WP_003412960.1 type II toxin-antitoxin system VapB family antitoxin -
QQ046_RS13290 (QQ046_13290) 2834297..2834698 + 402 WP_003412963.1 PIN domain-containing protein -
QQ046_RS13295 (QQ046_13295) 2834733..2835653 - 921 WP_003412965.1 restriction endonuclease -
QQ046_RS13300 (QQ046_13300) 2835994..2836239 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
QQ046_RS13305 (QQ046_13305) 2836298..2837248 + 951 WP_003911916.1 ERCC4 domain-containing protein -
QQ046_RS13310 (QQ046_13310) 2837249..2837668 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ046_RS13315 (QQ046_13315) 2837665..2837889 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
QQ046_RS13320 (QQ046_13320) 2837920..2840763 - 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
QQ046_RS13325 (QQ046_13325) 2840835..2841236 - 402 WP_003412981.1 hypothetical protein -
QQ046_RS13330 (QQ046_13330) 2841236..2841706 - 471 WP_003899364.1 transcription antitermination factor NusB -
QQ046_RS13335 (QQ046_13335) 2841709..2842272 - 564 WP_003412989.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T283789 WP_003412970.1 NZ_CP127273:c2837668-2837249 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT283789 WP_003412975.1 NZ_CP127273:c2837889-2837665 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ08

Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References