283788

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2791065..2791717 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name vapC Uniprot ID A0A5R1ZCY8
Locus tag QQ046_RS13115 Protein ID WP_003905869.1
Coordinates 2791292..2791717 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag QQ046_RS13110 Protein ID WP_003412749.1
Coordinates 2791065..2791286 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS13095 (QQ046_13095) 2789305..2789511 - 207 WP_003899347.1 hypothetical protein -
QQ046_RS13100 (QQ046_13100) 2789647..2790270 + 624 WP_003900858.1 TIGR00725 family protein -
QQ046_RS13105 (QQ046_13105) 2790260..2791012 + 753 WP_003901416.1 hypothetical protein -
QQ046_RS13110 (QQ046_13110) 2791065..2791286 + 222 WP_003412749.1 antitoxin Antitoxin
QQ046_RS13115 (QQ046_13115) 2791292..2791717 + 426 WP_003905869.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ046_RS13120 (QQ046_13120) 2791740..2792921 - 1182 WP_003905870.1 dihydrolipoamide acetyltransferase family protein -
QQ046_RS13125 (QQ046_13125) 2792918..2793964 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
QQ046_RS13130 (QQ046_13130) 2793975..2795078 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
QQ046_RS13135 (QQ046_13135) 2795337..2796158 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
QQ046_RS13140 (QQ046_13140) 2796155..2796712 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15364.84 Da        Isoelectric Point: 9.2386

>T283788 WP_003905869.1 NZ_CP127273:2791292-2791717 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT283788 WP_003412749.1 NZ_CP127273:2791065-2791286 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R1ZCY8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References