Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2347068..2347763 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QQ046_RS10985 Protein ID WP_003905754.1
Coordinates 2347068..2347502 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag QQ046_RS10990 Protein ID WP_003410814.1
Coordinates 2347509..2347763 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS10975 (QQ046_10975) 2343222..2346263 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
QQ046_RS10980 (QQ046_10980) 2346256..2347089 + 834 WP_003899172.1 SWIM zinc finger family protein -
QQ046_RS10985 (QQ046_10985) 2347068..2347502 - 435 WP_003905754.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ046_RS10990 (QQ046_10990) 2347509..2347763 - 255 WP_003410814.1 antitoxin Antitoxin
QQ046_RS10995 (QQ046_10995) 2347779..2348036 - 258 WP_003410816.1 hypothetical protein -
QQ046_RS11000 (QQ046_11000) 2348447..2349708 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
QQ046_RS11005 (QQ046_11005) 2350341..2350637 + 297 WP_003410820.1 PE family protein -
QQ046_RS11010 (QQ046_11010) 2350693..2351424 + 732 WP_003900467.1 PPE family protein -
QQ046_RS11015 (QQ046_11015) 2351965..2352711 - 747 WP_003901330.1 proteasome subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15632.05 Da        Isoelectric Point: 7.4681

>T283786 WP_003905754.1 NZ_CP127273:c2347502-2347068 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT283786 WP_003410814.1 NZ_CP127273:c2347763-2347509 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References