Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2217287..2217873 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag QQ046_RS10405 Protein ID WP_003410010.1
Coordinates 2217287..2217631 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag QQ046_RS10410 Protein ID WP_003410014.1
Coordinates 2217625..2217873 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS10370 (QQ046_10370) 2212993..2213592 + 600 WP_003910883.1 L-lysine exporter -
QQ046_RS10375 (QQ046_10375) 2214008..2214436 + 429 WP_003409992.1 cellulose-binding protein -
QQ046_RS10380 (QQ046_10380) 2214662..2215201 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
QQ046_RS10385 (QQ046_10385) 2215721..2216281 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
QQ046_RS10390 (QQ046_10390) 2216278..2216619 - 342 WP_003410003.1 DUF2384 domain-containing protein -
QQ046_RS10395 (QQ046_10395) 2216705..2216962 + 258 WP_003410006.1 hypothetical protein -
QQ046_RS10400 (QQ046_10400) 2216863..2217198 - 336 WP_003410009.1 dehydrogenase -
QQ046_RS10405 (QQ046_10405) 2217287..2217631 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
QQ046_RS10410 (QQ046_10410) 2217625..2217873 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
QQ046_RS10415 (QQ046_10415) 2217973..2220288 - 2316 WP_003899120.1 cation transporter ATPase CptG -
QQ046_RS10420 (QQ046_10420) 2220285..2220557 - 273 WP_003410017.1 DUF1490 family protein -
QQ046_RS10425 (QQ046_10425) 2220610..2220966 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
QQ046_RS10430 (QQ046_10430) 2221123..2221890 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T283782 WP_003410010.1 NZ_CP127273:c2217631-2217287 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT283782 WP_003410014.1 NZ_CP127273:c2217873-2217625 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
PDB 7WJ0
PDB 7WNR
AlphaFold DB A0A7U4FAW9

References