Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2215721..2216619 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag QQ046_RS10385 Protein ID WP_003410001.1
Coordinates 2215721..2216281 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag QQ046_RS10390 Protein ID WP_003410003.1
Coordinates 2216278..2216619 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS10355 (QQ046_10355) 2210890..2211543 - 654 WP_003409976.1 cutinase Cfp21 -
QQ046_RS10360 (QQ046_10360) 2211658..2211888 + 231 WP_003409980.1 DUF167 domain-containing protein -
QQ046_RS10365 (QQ046_10365) 2211973..2212884 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
QQ046_RS10370 (QQ046_10370) 2212993..2213592 + 600 WP_003910883.1 L-lysine exporter -
QQ046_RS10375 (QQ046_10375) 2214008..2214436 + 429 WP_003409992.1 cellulose-binding protein -
QQ046_RS10380 (QQ046_10380) 2214662..2215201 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
QQ046_RS10385 (QQ046_10385) 2215721..2216281 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
QQ046_RS10390 (QQ046_10390) 2216278..2216619 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
QQ046_RS10395 (QQ046_10395) 2216705..2216962 + 258 WP_003410006.1 hypothetical protein -
QQ046_RS10400 (QQ046_10400) 2216863..2217198 - 336 WP_003410009.1 dehydrogenase -
QQ046_RS10405 (QQ046_10405) 2217287..2217631 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
QQ046_RS10410 (QQ046_10410) 2217625..2217873 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
QQ046_RS10415 (QQ046_10415) 2217973..2220288 - 2316 WP_003899120.1 cation transporter ATPase CptG -
QQ046_RS10420 (QQ046_10420) 2220285..2220557 - 273 WP_003410017.1 DUF1490 family protein -
QQ046_RS10425 (QQ046_10425) 2220610..2220966 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T283781 WP_003410001.1 NZ_CP127273:c2216281-2215721 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT283781 WP_003410003.1 NZ_CP127273:c2216619-2216278 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References