Detailed information of TA system TA283780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2208395..2209083
• Replicon: chromosome
• Accession: NZ_CP127273
• Organism: Mycobacterium tuberculosis strain 3320

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P0A653
• Locus tag: QQ046_RS10340
• Protein ID: WP_003409958.1
• Coordinates: 2208395..2208814 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ28
• Locus tag: QQ046_RS10345
• Protein ID: WP_003409968.1
• Coordinates: 2208823..2209083 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QQ046_RS10320 (QQ046_10320)	2203890..2204738	+	849	WP_003901306.1	class I SAM-dependent methyltransferase	-
QQ046_RS10325 (QQ046_10325)	2204701..2206146	-	1446	WP_003899115.1	APC family permease	-
QQ046_RS10330 (QQ046_10330)	2206325..2207011	-	687	WP_003409954.1	immunoprotective protein Mpt64	-
QQ046_RS10335 (QQ046_10335)	2207202..2208170	-	969	WP_003899116.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
QQ046_RS10340 (QQ046_10340)	2208395..2208814	-	420	WP_003409958.1	type II toxin-antitoxin system VapC family toxin	Toxin
QQ046_RS10345 (QQ046_10345)	2208823..2209083	-	261	WP_003409968.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
QQ046_RS10350 (QQ046_10350)	2209226..2210902	+	1677	WP_003899118.1	PecA family PE domain-processing aspartic protease	-
QQ046_RS10355 (QQ046_10355)	2210890..2211543	-	654	WP_003409976.1	cutinase Cfp21	-
QQ046_RS10360 (QQ046_10360)	2211658..2211888	+	231	WP_003409980.1	DUF167 domain-containing protein	-
QQ046_RS10365 (QQ046_10365)	2211973..2212884	-	912	WP_003409986.1	ArgP/LysG family DNA-binding transcriptional regulator	-
QQ046_RS10370 (QQ046_10370)	2212993..2213592	+	600	WP_003910883.1	L-lysine exporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-125)

Antitoxin

• Antitoxin VapB-like (2-81)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14724.89 Da
• Isoelectric Point: 7.9535

>T283780 WP_003409958.1 NZ_CP127273:c2208814-2208395 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Nucleotide

• Length: 420 bp

>T283780 NZ_CP127273:c2208814-2208395 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9528.88 Da
• Isoelectric Point: 5.1007

>AT283780 WP_003409968.1 NZ_CP127273:c2209083-2208823 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Nucleotide

• Length: 261 bp

>AT283780 NZ_CP127273:c2209083-2208823 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Structures

Toxin

• AlphaFold DB: A0A829C4H9

Antitoxin

• AlphaFold DB: A0A829C483