Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1937114..1937727 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag QQ046_RS09040 Protein ID WP_003408465.1
Coordinates 1937114..1937503 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag QQ046_RS09045 Protein ID WP_003408469.1
Coordinates 1937500..1937727 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS09005 (QQ046_09005) 1932743..1933657 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
QQ046_RS09010 (QQ046_09010) 1933660..1934490 + 831 WP_003408448.1 cyclase family protein -
QQ046_RS09015 (QQ046_09015) 1934490..1934840 + 351 WP_003898986.1 cupin domain-containing protein -
QQ046_RS09020 (QQ046_09020) 1934893..1935711 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
QQ046_RS09025 (QQ046_09025) 1935725..1936504 + 780 WP_003408460.1 IclR family transcriptional regulator -
QQ046_RS09035 (QQ046_09035) 1936935..1937066 + 132 Protein_1782 IS3 family transposase -
QQ046_RS09040 (QQ046_09040) 1937114..1937503 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ046_RS09045 (QQ046_09045) 1937500..1937727 - 228 WP_003408469.1 antitoxin Antitoxin
QQ046_RS09050 (QQ046_09050) 1937945..1939429 + 1485 WP_003408473.1 biotin carboxylase -
QQ046_RS09055 (QQ046_09055) 1939426..1940673 + 1248 WP_003408476.1 serine hydrolase -
QQ046_RS09060 (QQ046_09060) 1940716..1941135 - 420 WP_003408483.1 hypothetical protein -
QQ046_RS09065 (QQ046_09065) 1941125..1941835 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T283775 WP_003408465.1 NZ_CP127273:c1937503-1937114 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT283775 WP_003408469.1 NZ_CP127273:c1937727-1937500 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References