Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1387993..1388552 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag QQ046_RS06640 Protein ID WP_003898789.1
Coordinates 1387993..1388286 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag QQ046_RS06645 Protein ID WP_003406322.1
Coordinates 1388283..1388552 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS06615 (QQ046_06615) 1383586..1383846 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
QQ046_RS06620 (QQ046_06620) 1383843..1384274 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
QQ046_RS06625 (QQ046_06625) 1384297..1385985 - 1689 WP_286014938.1 PE family protein -
QQ046_RS06630 (QQ046_06630) 1386165..1387025 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
QQ046_RS06635 (QQ046_06635) 1387106..1387936 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
QQ046_RS06640 (QQ046_06640) 1387993..1388286 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QQ046_RS06645 (QQ046_06645) 1388283..1388552 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QQ046_RS06650 (QQ046_06650) 1388665..1392360 - 3696 WP_003406323.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
QQ046_RS06655 (QQ046_06655) 1392502..1393290 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T283770 WP_003898789.1 NZ_CP127273:c1388286-1387993 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT283770 WP_003406322.1 NZ_CP127273:c1388552-1388283 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References