Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1383586..1384274 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag QQ046_RS06620 Protein ID WP_003406304.1
Coordinates 1383843..1384274 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag QQ046_RS06615 Protein ID WP_003406302.1
Coordinates 1383586..1383846 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS06595 (QQ046_06595) 1379163..1379987 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
QQ046_RS06600 (QQ046_06600) 1379992..1381173 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
QQ046_RS06605 (QQ046_06605) 1381250..1382350 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
QQ046_RS06610 (QQ046_06610) 1382521..1383510 + 990 WP_003406301.1 malate dehydrogenase -
QQ046_RS06615 (QQ046_06615) 1383586..1383846 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
QQ046_RS06620 (QQ046_06620) 1383843..1384274 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ046_RS06625 (QQ046_06625) 1384297..1385985 - 1689 WP_286014938.1 PE family protein -
QQ046_RS06630 (QQ046_06630) 1386165..1387025 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
QQ046_RS06635 (QQ046_06635) 1387106..1387936 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
QQ046_RS06640 (QQ046_06640) 1387993..1388286 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
QQ046_RS06645 (QQ046_06645) 1388283..1388552 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T283769 WP_003406304.1 NZ_CP127273:1383843-1384274 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT283769 WP_003406302.1 NZ_CP127273:1383586-1383846 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References