Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1229968..1230599 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag QQ046_RS05890 Protein ID WP_003405820.1
Coordinates 1229968..1230279 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag QQ046_RS05895 Protein ID WP_003405836.1
Coordinates 1230279..1230599 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS05870 (QQ046_05870) 1225449..1226873 - 1425 WP_003405805.1 class II fumarate hydratase -
QQ046_RS05875 (QQ046_05875) 1226904..1227992 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
QQ046_RS05880 (QQ046_05880) 1228048..1228692 + 645 WP_003915494.1 DUF4245 domain-containing protein -
QQ046_RS05885 (QQ046_05885) 1228699..1229856 - 1158 WP_003898727.1 AI-2E family transporter -
QQ046_RS05890 (QQ046_05890) 1229968..1230279 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
QQ046_RS05895 (QQ046_05895) 1230279..1230599 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
QQ046_RS05900 (QQ046_05900) 1230609..1232145 + 1537 Protein_1162 carboxylesterase/lipase family protein -
QQ046_RS05905 (QQ046_05905) 1232152..1233264 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
QQ046_RS05910 (QQ046_05910) 1233274..1233531 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
QQ046_RS05915 (QQ046_05915) 1233521..1234768 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
QQ046_RS05920 (QQ046_05920) 1234765..1235403 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T283767 WP_003405820.1 NZ_CP127273:c1230279-1229968 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT283767 WP_003405836.1 NZ_CP127273:c1230599-1230279 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References