Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1013989..1014608 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag QQ046_RS04815 Protein ID WP_003404726.1
Coordinates 1014174..1014608 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag QQ046_RS04810 Protein ID WP_003898641.1
Coordinates 1013989..1014168 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS04795 (QQ046_04795) 1009463..1011042 + 1580 Protein_945 serine hydrolase -
QQ046_RS04800 (QQ046_04800) 1011039..1013432 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
QQ046_RS04805 (QQ046_04805) 1013705..1013863 + 159 WP_003404720.1 hypothetical protein -
QQ046_RS04810 (QQ046_04810) 1013989..1014168 + 180 WP_003898641.1 antitoxin Antitoxin
QQ046_RS04815 (QQ046_04815) 1014174..1014608 + 435 WP_003404726.1 SRPBCC family protein Toxin
QQ046_RS04820 (QQ046_04820) 1014706..1015479 + 774 WP_003404735.1 VOC family protein -
QQ046_RS04825 (QQ046_04825) 1015544..1015993 + 450 WP_003404738.1 hypothetical protein -
QQ046_RS04830 (QQ046_04830) 1016128..1016358 - 231 WP_003898642.1 hypothetical protein -
QQ046_RS04835 (QQ046_04835) 1016525..1018033 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
QQ046_RS04840 (QQ046_04840) 1018035..1019273 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T283764 WP_003404726.1 NZ_CP127273:1014174-1014608 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT283764 WP_003898641.1 NZ_CP127273:1013989-1014168 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References