Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 754288..755080 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag QQ046_RS03490 Protein ID WP_003403386.1
Coordinates 754643..755080 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag QQ046_RS03485 Protein ID WP_003403381.1
Coordinates 754288..754533 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS03455 (QQ046_03455) 749308..750813 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
QQ046_RS03460 (QQ046_03460) 750894..751904 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
QQ046_RS03465 (QQ046_03465) 752292..752675 - 384 WP_003403365.1 ribonuclease VapC6 -
QQ046_RS03470 (QQ046_03470) 752770..752925 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
QQ046_RS03475 (QQ046_03475) 753001..753717 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
QQ046_RS03480 (QQ046_03480) 753993..754301 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
QQ046_RS03485 (QQ046_03485) 754288..754533 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
QQ046_RS03490 (QQ046_03490) 754643..755080 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ046_RS03495 (QQ046_03495) 755077..755331 - 255 WP_003911263.1 antitoxin VapB7 -
QQ046_RS03500 (QQ046_03500) 755445..757808 + 2364 WP_003901895.1 arylsulfatase AtsD -
QQ046_RS03505 (QQ046_03505) 757871..758197 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
QQ046_RS03510 (QQ046_03510) 758109..758447 + 339 WP_003403405.1 PIN domain-containing protein -
QQ046_RS03515 (QQ046_03515) 758444..758617 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T283761 WP_003403386.1 NZ_CP127273:c755080-754643 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT283761 WP_003403381.1 NZ_CP127273:c754533-754288 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References