Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 715718..716367 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag QQ046_RS03280 Protein ID WP_003403236.1
Coordinates 715972..716367 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag QQ046_RS03275 Protein ID WP_003403235.1
Coordinates 715718..715972 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS03250 (QQ046_03250) 710844..710927 + 84 Protein_644 galactose-1-phosphate uridylyltransferase -
QQ046_RS03255 (QQ046_03255) 710946..712027 + 1082 Protein_645 galactose-1-phosphate uridylyltransferase -
QQ046_RS03260 (QQ046_03260) 712024..713115 + 1092 WP_003900977.1 galactokinase -
QQ046_RS03265 (QQ046_03265) 713510..714574 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
QQ046_RS03270 (QQ046_03270) 714678..715625 + 948 WP_003403232.1 DUF732 domain-containing protein -
QQ046_RS03275 (QQ046_03275) 715718..715972 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
QQ046_RS03280 (QQ046_03280) 715972..716367 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
QQ046_RS03285 (QQ046_03285) 716461..717201 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
QQ046_RS03290 (QQ046_03290) 717333..717593 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
QQ046_RS03295 (QQ046_03295) 717590..717997 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
QQ046_RS03300 (QQ046_03300) 718069..719220 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
QQ046_RS03305 (QQ046_03305) 719313..721040 - 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T283757 WP_003403236.1 NZ_CP127273:715972-716367 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT283757 WP_003403235.1 NZ_CP127273:715718-715972 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References