Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 710090..710715 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag QQ046_RS03245 Protein ID WP_003403218.1
Coordinates 710314..710715 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag QQ046_RS03240 Protein ID WP_003403213.1
Coordinates 710090..710317 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS03215 (QQ046_03215) 705269..705490 - 222 WP_003898525.1 DUF4926 domain-containing protein -
QQ046_RS03220 (QQ046_03220) 705632..706237 + 606 WP_003898526.1 hypothetical protein -
QQ046_RS03225 (QQ046_03225) 706256..708823 - 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
QQ046_RS03230 (QQ046_03230) 708907..709656 + 750 WP_003898528.1 hypothetical protein -
QQ046_RS03235 (QQ046_03235) 709653..709895 + 243 WP_003403210.1 hypothetical protein -
QQ046_RS03240 (QQ046_03240) 710090..710317 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
QQ046_RS03245 (QQ046_03245) 710314..710715 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
QQ046_RS03250 (QQ046_03250) 710844..710927 + 84 Protein_644 galactose-1-phosphate uridylyltransferase -
QQ046_RS03255 (QQ046_03255) 710946..712027 + 1082 Protein_645 galactose-1-phosphate uridylyltransferase -
QQ046_RS03260 (QQ046_03260) 712024..713115 + 1092 WP_003900977.1 galactokinase -
QQ046_RS03265 (QQ046_03265) 713510..714574 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
QQ046_RS03270 (QQ046_03270) 714678..715625 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T283756 WP_003403218.1 NZ_CP127273:710314-710715 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT283756 WP_003403213.1 NZ_CP127273:710090-710317 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References