Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 702552..703195 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag QQ046_RS03195 Protein ID WP_003403187.1
Coordinates 702794..703195 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag QQ046_RS03190 Protein ID WP_003403184.1
Coordinates 702552..702797 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS03155 (QQ046_03155) 697832..698362 - 531 WP_003917320.1 two component system sensor kinase HK2 -
QQ046_RS03160 (QQ046_03160) 698346..699041 - 696 WP_003918099.1 two-component system response regulator TcrA -
QQ046_RS03165 (QQ046_03165) 699164..699475 + 312 WP_003403164.1 hypothetical protein -
QQ046_RS03170 (QQ046_03170) 699547..700497 + 951 WP_003900184.1 DUF1259 domain-containing protein -
QQ046_RS03175 (QQ046_03175) 700738..701322 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
QQ046_RS03180 (QQ046_03180) 701324..702034 + 711 Protein_630 IS607 family element RNA-guided endonuclease TnpB -
QQ046_RS03185 (QQ046_03185) 702037..702507 + 471 WP_003898523.1 hypothetical protein -
QQ046_RS03190 (QQ046_03190) 702552..702797 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QQ046_RS03195 (QQ046_03195) 702794..703195 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ046_RS03200 (QQ046_03200) 703186..703365 + 180 Protein_634 hypothetical protein -
QQ046_RS03205 (QQ046_03205) 703783..703980 - 198 WP_003403191.1 hypothetical protein -
QQ046_RS03210 (QQ046_03210) 704060..705217 - 1158 WP_003898524.1 hypothetical protein -
QQ046_RS03215 (QQ046_03215) 705269..705490 - 222 WP_003898525.1 DUF4926 domain-containing protein -
QQ046_RS03220 (QQ046_03220) 705632..706237 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T283755 WP_003403187.1 NZ_CP127273:702794-703195 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT283755 WP_003403184.1 NZ_CP127273:702552-702797 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References