Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 102738..103363 Replicon plasmid pQ501
Accession NZ_CP127256
Organism Escherichia coli strain Q5

Toxin (Protein)


Gene name vapC Uniprot ID A0A828AN07
Locus tag QQ972_RS24630 Protein ID WP_059257082.1
Coordinates 102738..103136 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8H9EG71
Locus tag QQ972_RS24635 Protein ID WP_000450526.1
Coordinates 103136..103363 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ972_RS24615 (98986) 98986..99489 + 504 WP_285985015.1 conjugal transfer entry exclusion protein TraS -
QQ972_RS24620 (99529) 99529..100260 + 732 WP_000850422.1 conjugal transfer complement resistance protein TraT -
QQ972_RS24625 (100513) 100513..102729 + 2217 WP_285985016.1 type IV conjugative transfer system coupling protein TraD -
QQ972_RS24630 (102738) 102738..103136 - 399 WP_059257082.1 tRNA(fMet)-specific endonuclease VapC Toxin
QQ972_RS24635 (103136) 103136..103363 - 228 WP_000450526.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroN / iroN / iroE / iroD / iroC / iroB / papH / papC / papD / vat / vat / afaC-I 1..137541 137541


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14945.27 Da        Isoelectric Point: 7.8605

>T283743 WP_059257082.1 NZ_CP127256:c103136-102738 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNIREFERMDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.53 Da        Isoelectric Point: 4.5358

>AT283743 WP_000450526.1 NZ_CP127256:c103363-103136 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGESWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828AN07

Antitoxin

Source ID Structure

References