Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1-PHD |
| Location | 2692435..2693078 | Replicon | chromosome |
| Accession | NC_018681 | ||
| Organism | Nocardia brasiliensis ATCC 700358 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | O3I_RS12060 | Protein ID | WP_014983194.1 |
| Coordinates | 2692686..2693078 (+) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | O3I_RS12055 | Protein ID | WP_041562571.1 |
| Coordinates | 2692435..2692689 (+) | Length | 85 a.a. |
Genomic Context
Location: 2688143..2689042 (900 bp)
Type: Others
Protein ID: WP_088606935.1
Type: Others
Protein ID: WP_088606935.1
Location: 2689039..2689758 (720 bp)
Type: Others
Protein ID: WP_014983188.1
Type: Others
Protein ID: WP_014983188.1
Location: 2689840..2690301 (462 bp)
Type: Others
Protein ID: WP_014983189.1
Type: Others
Protein ID: WP_014983189.1
Location: 2692435..2692689 (255 bp)
Type: Antitoxin
Protein ID: WP_041562571.1
Type: Antitoxin
Protein ID: WP_041562571.1
Location: 2692686..2693078 (393 bp)
Type: Toxin
Protein ID: WP_014983194.1
Type: Toxin
Protein ID: WP_014983194.1
Location: 2694767..2698054 (3288 bp)
Type: Others
Protein ID: WP_041562572.1
Type: Others
Protein ID: WP_041562572.1
Location: 2690298..2690729 (432 bp)
Type: Others
Protein ID: WP_014983190.1
Type: Others
Protein ID: WP_014983190.1
Location: 2690745..2691314 (570 bp)
Type: Others
Protein ID: WP_014983191.1
Type: Others
Protein ID: WP_014983191.1
Location: 2691304..2691960 (657 bp)
Type: Others
Protein ID: WP_014983192.1
Type: Others
Protein ID: WP_014983192.1
Location: 2693123..2693710 (588 bp)
Type: Others
Protein ID: WP_041563691.1
Type: Others
Protein ID: WP_041563691.1
Location: 2693752..2694651 (900 bp)
Type: Others
Protein ID: WP_014983196.1
Type: Others
Protein ID: WP_014983196.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| O3I_RS12025 | 2688143..2689042 | + | 900 | WP_088606935.1 | hypothetical protein | - |
| O3I_RS12030 | 2689039..2689758 | + | 720 | WP_014983188.1 | hypothetical protein | - |
| O3I_RS12035 | 2689840..2690301 | + | 462 | WP_014983189.1 | VOC family protein | - |
| O3I_RS12040 | 2690298..2690729 | - | 432 | WP_014983190.1 | Rieske 2Fe-2S domain-containing protein | - |
| O3I_RS12045 | 2690745..2691314 | - | 570 | WP_014983191.1 | hypothetical protein | - |
| O3I_RS12050 | 2691304..2691960 | - | 657 | WP_014983192.1 | hypothetical protein | - |
| O3I_RS12055 | 2692435..2692689 | + | 255 | WP_041562571.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| O3I_RS12060 | 2692686..2693078 | + | 393 | WP_014983194.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| O3I_RS12065 | 2693123..2693710 | - | 588 | WP_041563691.1 | NAD(P)H-dependent oxidoreductase | - |
| O3I_RS12070 | 2693752..2694651 | - | 900 | WP_014983196.1 | alpha/beta hydrolase | - |
| O3I_RS12075 | 2694767..2698054 | + | 3288 | WP_041562572.1 | winged helix-turn-helix domain-containing protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 14338.37 Da Isoelectric Point: 4.4606
>T28374 WP_014983194.1 NC_018681:2692686-2693078 [Nocardia brasiliensis ATCC 700358]
VNVEQALADTSIFIGLEAKRFDPAQIEGYELGVSVVTLGELRLGVLHATDPESAARRLSTYQLAQRFEPLAVDEKVAEQW
ALLVSRLRAAGRKVPINDSWIAATAMAYDIPIATQDNDYDAMPDLRIIKL
VNVEQALADTSIFIGLEAKRFDPAQIEGYELGVSVVTLGELRLGVLHATDPESAARRLSTYQLAQRFEPLAVDEKVAEQW
ALLVSRLRAAGRKVPINDSWIAATAMAYDIPIATQDNDYDAMPDLRIIKL
Download Length: 393 bp
>T28374 NC_018681:2692686-2693078 [Nocardia brasiliensis ATCC 700358]
GTGAACGTCGAGCAGGCGCTCGCCGATACTTCGATCTTCATCGGTTTGGAGGCCAAGCGCTTCGATCCGGCGCAAATCGA
AGGTTATGAGCTGGGCGTCTCTGTCGTCACGCTGGGTGAACTCCGCCTCGGTGTGCTGCACGCGACCGATCCGGAATCGG
CCGCTCGGCGCTTGTCGACTTACCAACTGGCCCAACGATTCGAGCCGCTCGCCGTCGATGAGAAGGTGGCCGAGCAGTGG
GCCCTCCTTGTCTCGCGTCTTCGGGCAGCCGGTCGCAAAGTGCCGATCAATGACAGTTGGATTGCCGCGACGGCGATGGC
CTATGACATTCCGATCGCCACCCAAGACAACGACTACGACGCCATGCCGGACCTTCGGATCATCAAGCTCTGA
GTGAACGTCGAGCAGGCGCTCGCCGATACTTCGATCTTCATCGGTTTGGAGGCCAAGCGCTTCGATCCGGCGCAAATCGA
AGGTTATGAGCTGGGCGTCTCTGTCGTCACGCTGGGTGAACTCCGCCTCGGTGTGCTGCACGCGACCGATCCGGAATCGG
CCGCTCGGCGCTTGTCGACTTACCAACTGGCCCAACGATTCGAGCCGCTCGCCGTCGATGAGAAGGTGGCCGAGCAGTGG
GCCCTCCTTGTCTCGCGTCTTCGGGCAGCCGGTCGCAAAGTGCCGATCAATGACAGTTGGATTGCCGCGACGGCGATGGC
CTATGACATTCCGATCGCCACCCAAGACAACGACTACGACGCCATGCCGGACCTTCGGATCATCAAGCTCTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9708.18 Da Isoelectric Point: 5.1768
>AT28374 WP_041562571.1 NC_018681:2692435-2692689 [Nocardia brasiliensis ATCC 700358]
MTALPARDLRNHTAEVLRRVEAGEEIEILKDNRPVAKIIPLPRRRQWIPATEIMQELIRLGPDTTGLRAELRETLTETTD
DLPW
MTALPARDLRNHTAEVLRRVEAGEEIEILKDNRPVAKIIPLPRRRQWIPATEIMQELIRLGPDTTGLRAELRETLTETTD
DLPW
Download Length: 255 bp
>AT28374 NC_018681:2692435-2692689 [Nocardia brasiliensis ATCC 700358]
ATGACTGCATTGCCGGCGCGGGACCTCCGCAATCACACCGCGGAGGTTTTGCGGCGTGTGGAGGCTGGGGAAGAAATCGA
GATTCTGAAGGACAATCGTCCGGTGGCGAAGATCATTCCGTTGCCTCGGCGGCGGCAGTGGATTCCGGCAACCGAGATCA
TGCAGGAGTTGATCCGGCTCGGCCCCGATACGACAGGTCTGCGTGCGGAGCTGCGGGAGACCTTGACCGAGACGACGGAC
GATCTGCCGTGGTGA
ATGACTGCATTGCCGGCGCGGGACCTCCGCAATCACACCGCGGAGGTTTTGCGGCGTGTGGAGGCTGGGGAAGAAATCGA
GATTCTGAAGGACAATCGTCCGGTGGCGAAGATCATTCCGTTGCCTCGGCGGCGGCAGTGGATTCCGGCAACCGAGATCA
TGCAGGAGTTGATCCGGCTCGGCCCCGATACGACAGGTCTGCGTGCGGAGCTGCGGGAGACCTTGACCGAGACGACGGAC
GATCTGCCGTGGTGA