Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 2692435..2693078 Replicon chromosome
Accession NC_018681
Organism Nocardia brasiliensis ATCC 700358

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag O3I_RS12060 Protein ID WP_014983194.1
Coordinates 2692686..2693078 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag O3I_RS12055 Protein ID WP_041562571.1
Coordinates 2692435..2692689 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3I_RS12025 2688143..2689042 + 900 WP_088606935.1 hypothetical protein -
O3I_RS12030 2689039..2689758 + 720 WP_014983188.1 hypothetical protein -
O3I_RS12035 2689840..2690301 + 462 WP_014983189.1 VOC family protein -
O3I_RS12040 2690298..2690729 - 432 WP_014983190.1 Rieske 2Fe-2S domain-containing protein -
O3I_RS12045 2690745..2691314 - 570 WP_014983191.1 hypothetical protein -
O3I_RS12050 2691304..2691960 - 657 WP_014983192.1 hypothetical protein -
O3I_RS12055 2692435..2692689 + 255 WP_041562571.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
O3I_RS12060 2692686..2693078 + 393 WP_014983194.1 type II toxin-antitoxin system VapC family toxin Toxin
O3I_RS12065 2693123..2693710 - 588 WP_041563691.1 NAD(P)H-dependent oxidoreductase -
O3I_RS12070 2693752..2694651 - 900 WP_014983196.1 alpha/beta hydrolase -
O3I_RS12075 2694767..2698054 + 3288 WP_041562572.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14338.37 Da        Isoelectric Point: 4.4606

>T28374 WP_014983194.1 NC_018681:2692686-2693078 [Nocardia brasiliensis ATCC 700358]
VNVEQALADTSIFIGLEAKRFDPAQIEGYELGVSVVTLGELRLGVLHATDPESAARRLSTYQLAQRFEPLAVDEKVAEQW
ALLVSRLRAAGRKVPINDSWIAATAMAYDIPIATQDNDYDAMPDLRIIKL

Download         Length: 393 bp

>T28374 NC_018681:2692686-2693078 [Nocardia brasiliensis ATCC 700358]
GTGAACGTCGAGCAGGCGCTCGCCGATACTTCGATCTTCATCGGTTTGGAGGCCAAGCGCTTCGATCCGGCGCAAATCGA
AGGTTATGAGCTGGGCGTCTCTGTCGTCACGCTGGGTGAACTCCGCCTCGGTGTGCTGCACGCGACCGATCCGGAATCGG
CCGCTCGGCGCTTGTCGACTTACCAACTGGCCCAACGATTCGAGCCGCTCGCCGTCGATGAGAAGGTGGCCGAGCAGTGG
GCCCTCCTTGTCTCGCGTCTTCGGGCAGCCGGTCGCAAAGTGCCGATCAATGACAGTTGGATTGCCGCGACGGCGATGGC
CTATGACATTCCGATCGCCACCCAAGACAACGACTACGACGCCATGCCGGACCTTCGGATCATCAAGCTCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9708.18 Da        Isoelectric Point: 5.1768

>AT28374 WP_041562571.1 NC_018681:2692435-2692689 [Nocardia brasiliensis ATCC 700358]
MTALPARDLRNHTAEVLRRVEAGEEIEILKDNRPVAKIIPLPRRRQWIPATEIMQELIRLGPDTTGLRAELRETLTETTD
DLPW

Download         Length: 255 bp

>AT28374 NC_018681:2692435-2692689 [Nocardia brasiliensis ATCC 700358]
ATGACTGCATTGCCGGCGCGGGACCTCCGCAATCACACCGCGGAGGTTTTGCGGCGTGTGGAGGCTGGGGAAGAAATCGA
GATTCTGAAGGACAATCGTCCGGTGGCGAAGATCATTCCGTTGCCTCGGCGGCGGCAGTGGATTCCGGCAACCGAGATCA
TGCAGGAGTTGATCCGGCTCGGCCCCGATACGACAGGTCTGCGTGCGGAGCTGCGGGAGACCTTGACCGAGACGACGGAC
GATCTGCCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References