Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4795728..4796382 Replicon chromosome
Accession NZ_CP127255
Organism Escherichia coli strain Q5

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QQ972_RS23220 Protein ID WP_000244781.1
Coordinates 4795728..4796135 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QQ972_RS23225 Protein ID WP_000354046.1
Coordinates 4796116..4796382 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ972_RS23200 (4791685) 4791685..4793418 - 1734 WP_000813193.1 single-stranded-DNA-specific exonuclease RecJ -
QQ972_RS23205 (4793424) 4793424..4794134 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QQ972_RS23210 (4794159) 4794159..4795055 - 897 WP_097751990.1 site-specific tyrosine recombinase XerD -
QQ972_RS23215 (4795167) 4795167..4795688 + 522 WP_001055874.1 flavodoxin FldB -
QQ972_RS23220 (4795728) 4795728..4796135 - 408 WP_000244781.1 protein YgfX Toxin
QQ972_RS23225 (4796116) 4796116..4796382 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QQ972_RS23230 (4796625) 4796625..4797605 + 981 WP_000886080.1 tRNA-modifying protein YgfZ -
QQ972_RS23235 (4797682) 4797682..4798341 - 660 WP_000250274.1 hemolysin III family protein -
QQ972_RS23240 (4798505) 4798505..4798816 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QQ972_RS23245 (4798861) 4798861..4800294 + 1434 WP_285984905.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T283737 WP_000244781.1 NZ_CP127255:c4796135-4795728 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT283737 WP_000354046.1 NZ_CP127255:c4796382-4796116 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References