Detailed information of TA system TA028373

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 1353219..1354177
• Replicon: chromosome
• Accession: NC_018681
• Organism: Nocardia brasiliensis ATCC 700358

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: O3I_RS05915
• Protein ID: WP_014981988.1
• Coordinates: 1353219..1353785 (-)
• Length: 189 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: O3I_RS05920
• Protein ID: WP_141692211.1
• Coordinates: 1353788..1354177 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
O3I_RS05885	1348328..1348876	+	549	WP_014981982.1	PH domain-containing protein	-
O3I_RS05890	1348899..1349576	+	678	WP_014981983.1	response regulator transcription factor	-
O3I_RS05895	1349578..1350885	+	1308	WP_041562432.1	HAMP domain-containing histidine kinase	-
O3I_RS05900	1350903..1351442	-	540	WP_029897843.1	GtrA family protein	-
O3I_RS05905	1351481..1352704	+	1224	WP_041563432.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
O3I_RS05910	1352718..1353218	+	501	WP_041562433.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
O3I_RS05915	1353219..1353785	-	567	WP_014981988.1	PIN domain-containing protein	Toxin
O3I_RS05920	1353788..1354177	-	390	WP_141692211.1	helix-turn-helix domain-containing protein	Antitoxin
O3I_RS05925	1354366..1355025	+	660	WP_014981990.1	TetR family transcriptional regulator	-
O3I_RS05930	1355185..1356342	+	1158	WP_014981991.1	acyl-CoA dehydrogenase	-
O3I_RS05935	1356398..1358497	-	2100	WP_014981992.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-112)

Antitoxin

• SinI-like, DNA-binding domain (61-105)

Sequences

Toxin

Protein

• Length: 189 a.a.
• Molecular weight: 20244.05 Da
• Isoelectric Point: 4.0206

>T28373 WP_014981988.1 NC_018681:c1353785-1353219 [Nocardia brasiliensis ATCC 700358]
MAFVVVYDANVLYGNALRDLLIRIAMSGSVQAKWTDKILDEALASLADKRPDIPTPKLTRLRGLMNKAVPDSLVYGYEPL
IEGLKLPDPDDRHVLAAAIAVGAQVIVTSNLADFPSDALAPWNIEAQSPDDFLLDQIDFDDRVVWACIQQIADSHINPPE
TVEDVLDALDSAGLVEAVAALRAGGLDG

Nucleotide

• Length: 567 bp

>T28373 NC_018681:c1353785-1353219 [Nocardia brasiliensis ATCC 700358]
ATGGCCTTCGTCGTGGTGTACGACGCCAACGTCCTCTACGGAAATGCGCTACGCGACTTGTTGATTCGAATTGCGATGTC
CGGCTCCGTGCAAGCGAAATGGACGGACAAGATCCTCGACGAAGCTCTGGCGAGTCTGGCGGACAAACGGCCCGACATTC
CCACCCCGAAACTGACCCGACTTCGCGGACTGATGAACAAGGCAGTTCCAGACAGTCTCGTCTACGGCTACGAGCCTCTC
ATCGAGGGTCTGAAGCTGCCCGACCCCGACGACCGCCACGTACTCGCGGCGGCCATTGCCGTCGGCGCCCAGGTCATTGT
GACGTCCAACCTCGCCGACTTTCCTTCAGATGCGTTGGCACCGTGGAATATCGAGGCACAGAGTCCCGACGACTTTCTGC
TCGACCAGATCGACTTCGACGACCGAGTGGTCTGGGCGTGCATCCAGCAGATCGCGGACTCGCACATCAATCCGCCGGAA
ACCGTCGAGGATGTGCTCGACGCGCTGGATAGCGCGGGCCTCGTGGAAGCGGTTGCGGCCCTACGCGCAGGCGGCCTCGA
CGGCTGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14594.62 Da
• Isoelectric Point: 6.6471

>AT28373 WP_141692211.1 NC_018681:c1354177-1353788 [Nocardia brasiliensis ATCC 700358]
MRRIKDYLMQHPTEQNIQVTREHPGEDALVLPREAVSLLAFILTQAAEGRGVSVVPSHAELTTQQAADMLNVSRPYVIAL
LEADEIPFRLVGRHRRIRYEDLKEYQQRNQAKSKAAADELAHLGQDLGI

Nucleotide

• Length: 390 bp

>AT28373 NC_018681:c1354177-1353788 [Nocardia brasiliensis ATCC 700358]
ATGCGGCGGATCAAGGACTACCTGATGCAGCACCCCACGGAACAAAACATCCAGGTGACGAGAGAGCACCCAGGCGAAGA
CGCTCTGGTCCTGCCCCGAGAAGCTGTCAGCCTGCTCGCATTCATCCTGACGCAGGCCGCCGAAGGCCGCGGCGTGTCGG
TAGTTCCCTCGCATGCCGAACTCACTACTCAGCAAGCAGCCGACATGTTGAACGTTTCCCGCCCGTATGTGATCGCTCTC
CTGGAGGCCGACGAGATTCCGTTCCGCCTCGTCGGCCGTCATCGGCGGATCAGATACGAAGACCTCAAGGAATACCAGCA
GCGGAACCAAGCGAAAAGCAAAGCCGCAGCAGACGAACTCGCTCATCTCGGCCAAGATCTCGGCATCTGA