Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2223215..2223833 Replicon chromosome
Accession NZ_CP127255
Organism Escherichia coli strain Q5

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQ972_RS10580 Protein ID WP_001291435.1
Coordinates 2223215..2223433 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQ972_RS10585 Protein ID WP_000344800.1
Coordinates 2223459..2223833 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ972_RS10545 (2218502) 2218502..2219074 + 573 WP_000779831.1 YbaY family lipoprotein -
QQ972_RS10550 (2219105) 2219105..2219416 - 312 WP_000409908.1 MGMT family protein -
QQ972_RS10560 (2219795) 2219795..2220148 + 354 WP_000878140.1 DUF1428 domain-containing protein -
QQ972_RS10565 (2220190) 2220190..2221740 - 1551 WP_001298569.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQ972_RS10570 (2221904) 2221904..2222374 - 471 WP_000136192.1 YlaC family protein -
QQ972_RS10575 (2222490) 2222490..2223041 - 552 WP_000102539.1 maltose O-acetyltransferase -
QQ972_RS10580 (2223215) 2223215..2223433 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QQ972_RS10585 (2223459) 2223459..2223833 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQ972_RS10590 (2224377) 2224377..2227526 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QQ972_RS10595 (2227549) 2227549..2228742 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283723 WP_001291435.1 NZ_CP127255:c2223433-2223215 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT283723 WP_000344800.1 NZ_CP127255:c2223833-2223459 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References