Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1734811..1735361 Replicon chromosome
Accession NZ_CP127255
Organism Escherichia coli strain Q5

Toxin (Protein)


Gene name ccdB Uniprot ID A0A8H8ZN44
Locus tag QQ972_RS08325 Protein ID WP_001160969.1
Coordinates 1735047..1735361 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag QQ972_RS08320 Protein ID WP_000125566.1
Coordinates 1734811..1735044 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ972_RS08295 (1729884) 1729884..1730171 + 288 WP_000203741.1 ferredoxin-like protein FixX -
QQ972_RS08300 (1730230) 1730230..1731561 + 1332 WP_001183207.1 MFS transporter -
QQ972_RS08305 (1731669) 1731669..1732199 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
QQ972_RS08310 (1732192) 1732192..1734054 + 1863 WP_097752025.1 glutathione-regulated potassium-efflux system protein KefC -
QQ972_RS08315 (1734246) 1734246..1734725 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
QQ972_RS08320 (1734811) 1734811..1735044 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QQ972_RS08325 (1735047) 1735047..1735361 + 315 WP_001160969.1 CcdB family protein Toxin
QQ972_RS08330 (1735358) 1735358..1736206 - 849 WP_285984968.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
QQ972_RS08335 (1736213) 1736213..1736590 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
QQ972_RS08340 (1736593) 1736593..1737414 - 822 WP_001065366.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
QQ972_RS08345 (1737411) 1737411..1738399 - 989 Protein_1620 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
QQ972_RS08350 (1738399) 1738399..1739685 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11681.65 Da        Isoelectric Point: 9.0851

>T283721 WP_001160969.1 NZ_CP127255:1735047-1735361 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIVGEINRRIVIPLTPIERFSRIRPPERLNPILLPVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT283721 WP_000125566.1 NZ_CP127255:1734811-1735044 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References