Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 1398462..1398959 Replicon chromosome
Accession NZ_CP127255
Organism Escherichia coli strain Q5

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QQ972_RS06755 Protein ID WP_001173343.1
Coordinates 1398786..1398959 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QQ972_RS06750 Protein ID WP_001312331.1
Coordinates 1398462..1398758 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ972_RS06730 (1395191) 1395191..1395910 - 720 WP_000611291.1 two-component system response regulator DcuR -
QQ972_RS06735 (1395907) 1395907..1397538 - 1632 WP_001216466.1 sensor histidine kinase -
QQ972_RS06740 (1397719) 1397719..1397949 + 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
QQ972_RS06745 (1397961) 1397961..1398233 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
QQ972_RS06750 (1398462) 1398462..1398758 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QQ972_RS06755 (1398786) 1398786..1398959 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QQ972_RS06760 (1399078) 1399078..1400595 - 1518 WP_000003806.1 lysine--tRNA ligase -
QQ972_RS06765 (1400832) 1400832..1402289 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T283719 WP_001173343.1 NZ_CP127255:1398786-1398959 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT283719 WP_001312331.1 NZ_CP127255:1398462-1398758 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References