Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 18672..19500 Replicon chromosome
Accession NZ_CP127255
Organism Escherichia coli strain Q5

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag QQ972_RS00090 Protein ID WP_089569554.1
Coordinates 19126..19500 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag QQ972_RS00085 Protein ID WP_024230663.1
Coordinates 18672..19037 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ972_RS00065 (16427) 16427..17245 + 819 WP_285984910.1 DUF932 domain-containing protein -
QQ972_RS00070 (17337) 17337..17822 + 486 WP_097751936.1 antirestriction protein -
QQ972_RS00075 (17838) 17838..18314 + 477 WP_001351157.1 RadC family protein -
QQ972_RS00080 (18377) 18377..18598 + 222 WP_000692323.1 DUF987 domain-containing protein -
QQ972_RS00085 (18672) 18672..19037 + 366 WP_024230663.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QQ972_RS00090 (19126) 19126..19500 + 375 WP_089569554.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
QQ972_RS00095 (19500) 19500..19697 + 198 Protein_18 DUF5983 family protein -
QQ972_RS00100 (19725) 19725..19922 + 198 WP_023563519.1 DUF957 domain-containing protein -
QQ972_RS00105 (20007) 20007..20848 + 842 Protein_20 DUF4942 domain-containing protein -
QQ972_RS00110 (21128) 21128..21664 - 537 WP_000942816.1 GspM family type II secretion system protein YghD -
QQ972_RS00115 (21666) 21666..22844 - 1179 WP_053294551.1 type II secretion system protein GspL -
QQ972_RS00120 (22841) 22841..23818 - 978 WP_097751935.1 type II secretion system minor pseudopilin GspK -
QQ972_RS00125 (23815) 23815..24420 - 606 WP_001250457.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(17-116)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13800.77 Da        Isoelectric Point: 6.4612

>T283717 WP_089569554.1 NZ_CP127255:19126-19500 [Escherichia coli]
MKTLPVLPGQAASSRLSPVEIWQILLSRLLDQHYGLTLDDTPFADERVIEQHIEAGISLCDAVNFLVEKYTLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13494.31 Da        Isoelectric Point: 6.4648

>AT283717 WP_024230663.1 NZ_CP127255:18672-19037 [Escherichia coli]
VSDTLPGTTHPDNNNRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSGE
LSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKT

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References