Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 29207..29850 Replicon plasmid pC4101
Accession NZ_CP127254
Organism Escherichia coli strain C41

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag QQ971_RS24830 Protein ID WP_001044768.1
Coordinates 29207..29623 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag QQ971_RS24835 Protein ID WP_001261287.1
Coordinates 29620..29850 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ971_RS24815 (25706) 25706..26296 - 591 WP_000194578.1 hypothetical protein -
QQ971_RS24820 (26296) 26296..26553 - 258 WP_000371891.1 hypothetical protein -
QQ971_RS24825 (26907) 26907..29045 + 2139 WP_000350638.1 AAA family ATPase -
QQ971_RS24830 (29207) 29207..29623 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ971_RS24835 (29620) 29620..29850 - 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QQ971_RS24840 (30146) 30146..30436 + 291 WP_000111771.1 hypothetical protein -
QQ971_RS24845 (30426) 30426..31325 + 900 WP_000963206.1 nucleotide-binding protein -
QQ971_RS24850 (31375) 31375..33600 - 2226 WP_000698737.1 P-loop NTPase fold protein -
QQ971_RS24855 (33712) 33712..34305 + 594 Protein_33 IS21-like element IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..114529 114529


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T283712 WP_001044768.1 NZ_CP127254:c29623-29207 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT283712 WP_001261287.1 NZ_CP127254:c29850-29620 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References