Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3798..4423 Replicon plasmid pC4101
Accession NZ_CP127254
Organism Escherichia coli strain C41

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QQ971_RS24710 Protein ID WP_000911324.1
Coordinates 3798..4196 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag QQ971_RS24715 Protein ID WP_000450532.1
Coordinates 4196..4423 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ971_RS24695 (106) 106..627 + 522 WP_000632670.1 conjugal transfer entry exclusion protein TraS -
QQ971_RS24700 (652) 652..1383 + 732 WP_000850422.1 conjugal transfer complement resistance protein TraT -
QQ971_RS24705 (1636) 1636..3789 + 2154 WP_286004812.1 type IV conjugative transfer system coupling protein TraD -
QQ971_RS24710 (3798) 3798..4196 - 399 WP_000911324.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ971_RS24715 (4196) 4196..4423 - 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..114529 114529


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-125)

Antitoxin

(7-51)


Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 14800.09 Da        Isoelectric Point: 7.8604

>T283711 WP_000911324.1 NZ_CP127254:c4196-3798 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMEVIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELALQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp


Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT283711 WP_000450532.1 NZ_CP127254:c4423-4196 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References