Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4113543..4114168 Replicon chromosome
Accession NZ_CP127252
Organism Escherichia coli strain C41

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QQ971_RS20160 Protein ID WP_000911330.1
Coordinates 4113543..4113941 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QQ971_RS20165 Protein ID WP_000450524.1
Coordinates 4113941..4114168 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ971_RS20140 (4109421) 4109421..4109621 + 201 WP_000383836.1 YpfN family protein -
QQ971_RS20145 (4109731) 4109731..4110429 - 699 WP_000679812.1 esterase -
QQ971_RS20150 (4110503) 4110503..4112518 - 2016 WP_089638850.1 tRNA cytosine(34) acetyltransferase TmcA -
QQ971_RS20155 (4112533) 4112533..4113396 - 864 WP_001267495.1 neutral zinc metallopeptidase -
QQ971_RS20160 (4113543) 4113543..4113941 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ971_RS20165 (4113941) 4113941..4114168 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QQ971_RS20170 (4114322) 4114322..4115035 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QQ971_RS20175 (4115248) 4115248..4116282 - 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
QQ971_RS20180 (4116299) 4116299..4117177 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QQ971_RS20185 (4117323) 4117323..4117895 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QQ971_RS20190 (4117895) 4117895..4118365 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T283706 WP_000911330.1 NZ_CP127252:c4113941-4113543 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT283706 WP_000450524.1 NZ_CP127252:c4114168-4113941 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References