Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1787470..1788088 Replicon chromosome
Accession NZ_CP127252
Organism Escherichia coli strain C41

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQ971_RS08535 Protein ID WP_001291435.1
Coordinates 1787470..1787688 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQ971_RS08540 Protein ID WP_000344800.1
Coordinates 1787714..1788088 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ971_RS08500 (1782759) 1782759..1783331 + 573 WP_000779826.1 YbaY family lipoprotein -
QQ971_RS08505 (1783362) 1783362..1783673 - 312 WP_000409911.1 MGMT family protein -
QQ971_RS08515 (1784052) 1784052..1784405 + 354 WP_000878141.1 DUF1428 family protein -
QQ971_RS08520 (1784447) 1784447..1785997 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQ971_RS08525 (1786161) 1786161..1786631 - 471 WP_000136192.1 YlaC family protein -
QQ971_RS08530 (1786747) 1786747..1787298 - 552 WP_000102564.1 maltose O-acetyltransferase -
QQ971_RS08535 (1787470) 1787470..1787688 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QQ971_RS08540 (1787714) 1787714..1788088 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQ971_RS08545 (1788634) 1788634..1791783 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QQ971_RS08550 (1791806) 1791806..1792999 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283692 WP_001291435.1 NZ_CP127252:c1787688-1787470 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT283692 WP_000344800.1 NZ_CP127252:c1788088-1787714 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References