283691

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1753174..1754011 Replicon chromosome
Accession NZ_CP127252
Organism Escherichia coli strain C41

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag QQ971_RS08365 Protein ID WP_000227784.1
Coordinates 1753174..1753716 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag QQ971_RS08370 Protein ID WP_001297137.1
Coordinates 1753700..1754011 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ971_RS08345 (1748713) 1748713..1749624 - 912 WP_000705853.1 2-dehydropantoate 2-reductase -
QQ971_RS08350 (1749792) 1749792..1750283 + 492 WP_001138904.1 nucleotide binding protein YajQ -
QQ971_RS08355 (1750411) 1750411..1751775 - 1365 WP_001000960.1 MFS transporter -
QQ971_RS08360 (1752183) 1752183..1753118 + 936 WP_001368479.1 tetratricopeptide repeat protein -
QQ971_RS08365 (1753174) 1753174..1753716 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
QQ971_RS08370 (1753700) 1753700..1754011 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
QQ971_RS08375 (1754196) 1754196..1755086 - 891 WP_000971336.1 heme o synthase -
QQ971_RS08380 (1755098) 1755098..1755427 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
QQ971_RS08385 (1755427) 1755427..1756041 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
QQ971_RS08390 (1756031) 1756031..1758022 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
QQ971_RS08395 (1758044) 1758044..1758991 - 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T283691 WP_000227784.1 NZ_CP127252:c1753716-1753174 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT283691 WP_001297137.1 NZ_CP127252:c1754011-1753700 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References