283689

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1029584..1030179 Replicon chromosome
Accession NZ_CP127252
Organism Escherichia coli strain C41

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QQ971_RS04895 Protein ID WP_000239579.1
Coordinates 1029829..1030179 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QQ971_RS04890 Protein ID WP_001223208.1
Coordinates 1029584..1029835 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ971_RS04880 (1025246) 1025246..1029027 + 3782 Protein_937 autotransporter assembly complex protein TamB -
QQ971_RS04885 (1029030) 1029030..1029371 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QQ971_RS04890 (1029584) 1029584..1029835 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QQ971_RS04895 (1029829) 1029829..1030179 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QQ971_RS04900 (1030259) 1030259..1030789 - 531 WP_000055075.1 inorganic diphosphatase -
QQ971_RS04905 (1031099) 1031099..1032055 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QQ971_RS04910 (1032195) 1032195..1033696 + 1502 Protein_943 sugar ABC transporter ATP-binding protein -
QQ971_RS04915 (1033710) 1033710..1034732 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T283689 WP_000239579.1 NZ_CP127252:1029829-1030179 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT283689 WP_001223208.1 NZ_CP127252:1029584-1029835 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References